Original scientific paper

Gizem Ari¹ , Mesut Cerit , Selin Yıldırım Tuncer¹, Didem Çatalo² , Jonida Balla³ , Metin Dalip⁴

https://doi.org/10.46733/PESH2514285a

Abstract

Background: Vitamin D deficiency is associated with impaired muscle strength, endurance, and recovery. Variants of the GC gene, particularly the rs2282679 polymorphism, influence circulating 25-hydroxyvitamin D and may affect exercise performance.Methods: This study examined the effects of the GC rs2282679 polymorphism on performance outcomes in 62 active adult men (AA=35, AC=24, CC=3). Genotyping was performed from oral swab samples. Aerobic performance was assessed using the Yo-Yo Intermittent Recovery Test Level 2 (Yo-Yo IR2) before and after a 6-week training program.

Results: At baseline, Yo-Yo IR2 means were 612.0±199.9 m for AA and 636.7±212.1 m for AC (p=0.651). Height differed significantly between AA (178.7±10.9 cm) and AC (184.7±11.8 cm; p=0.047), while weight and BMI showed no significant differences (p>0.05). Pre–post comparisons revealed significant improvements in Yo-Yo IR2 in both AA (p<0.001) and AC (p=0.003) groups. The CC group (n=3) was reported descriptively only.Conclusion: The GC rs2282679 polymorphism was not associated with baseline Yo-Yo IR2 performance but may influence training-related adaptations. These findings suggest a potential role for vitamin D–related genotypes in modulating aerobic capacity in active men. Further studies with larger CC samples are warranted.

Key words: Exercises; Vitamin D; Genotype

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